JWH-018 (1-pentyl-3-(1-naphthoyl)indole) is an analgesic chemical from the naphthoylindole family, which acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals very similar to those of THC.

History

Dr. John W. Huffman, an organic chemist at Clemson University, synthesizes analogues and metabolites of delta-9-tetrahydrocannabinol (THC), the principal active component of marijuana. JWH-018 is one of these analogues, with studies showing an affinity for the cannabinoid brain (CB1) receptor five times greater than that of THC. Cannabinoid receptors are found in mammalian brain and spleen tissue; however, the structural details of the active sites are currently unknown.

On December 15, 2008, it was reported by the German pharmaceutical company THC Pharm, that JWH-018 was found as one of the active components in at least three versions of the herbal blend Spice, which has been sold as an incense, in a number of countries around the world since 2002. An analysis of samples acquired four weeks after the German prohibition of JWH-018 took place found that the compound had been replaced with JWH-073.

Common dosage

The usual dosage for individual consumption (orally) varies greatly per individual but is typically between 3 and 20 milligrams. When smoked (as opposed to consumed orally) the amount needed may be lower, however the observed effects have a shorter duration.

From Wikipedia under the GNU Free Documentation License
Sat Jul 31 01:51:55 2010

What can dissolve jwh-018?
Q. I have been using acetone, which works quite well, but it leaves a strong scent that's hard to go away. I also used isopropyl alcohol and vodka (both which leave it sitting at the bottom without dissolving). And frankly Im not a fan of inhaling acetone. Can someone please tell me if there is another not so toxic chemical that will completely dissolve the chemical powder jwh-018?
Asked by christy - Sat Feb 6 11:34:53 2010 - - 2 Answers - 0 Comments

A. Dissolve 250mg of JWH into 100mL of 190-proof Everclear. You must use 190 proof Everclear, which is available in my local liquor store down the street but may also be ordered online. The math holds, so if you have 1000mg (1 gram) of JWH, dissolve into 400mL of 190-proof Everclear. I have personally done this with half-and-half of JWH-018 and JWH-073, 500mg a piece into 400mL Everclear. I d recommend pouring the Everclear into a clear wide-mouthed receptacle with a mL scale on the side, like one of those large Pyrex measuring cups or beakers. Most of the JWH will dissolve in the Everclear, except for a very small pile which will settle at the bottom. You will want to crush this up by using something like a wooden spoon or potato masher… [cont.]
Answered by Brian - Mon Feb 8 06:02:03 2010

Jwh-018 recommended sites?
Q. Why not let people know your experiences !! The idea behind this thread is for us to share, or recommend sites, that we have used based on price, quality and reliability. And to help stop people getting ripped off !!! like i have been This is the site that I use and recommend jwh-018.org totally genuine and the price you see is the price you pay, and its free signed for delivery, not like some other sites that boost the cost by adding extra charges, god I should be on commission, but me and a friend have both been very happy with the price quality and quick delivery from these guys, I have heard of some scams where people have not received their stuff, but these guys have been excellent.. jwh-018.org all the best Richie
Asked by Rich - Mon May 24 11:46:33 2010 - - 1 Answers - 0 Comments

A. Well, there are already forums for people to discuss things like that. And most of the community frowns upon publicizing vendors and sources. And since I was unable to find any history on that site, I would assume you are running it and trying to scam people yourself.
Answered by sky - Tue May 25 13:58:37 2010

Would JWH-018 fail a military drug test?
Q. Would JWH-018 fail a military drug test?
Asked by A for Anarchy - Wed Jan 27 20:16:40 2010 - - 2 Answers - 1 Comments

A. No, and you can buy it at a trusted site for cheap! www.jwh018usa.net
Answered by Bry guy - Sat Jan 30 12:27:11 2010

From Yahoo Answer Search: "JWH-018"
Sat Jul 31 01:17:48 2010

Who are you and why are you here? - ScienceBlogs (blog)
scienceblogs.com
Who are you and why are you here? - ScienceBlogs (blog)
Tue, 06 Jul 2010 18:18:50 GMT+00:00
ScienceBlogs (blog) ... yet readership is growing even beyond the sustained interest in our post on JWH-018 , the primary active component in synthetic marijuana products, ...
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From Google News Search: "JWH-018"
Fri Jul 30 22:28:08 2010

spice 11214121 mbqf jpg
bild.de
spice 11214121 mbqf jpg
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[source page]



Wird Spice bald verboten kevindooley Flickr
kraeuterallerlei.de
Wird Spice bald verboten kevindooley Flickr
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[source page]

sieht das Gesetzt vor den Verkauf zunaechst fuer 14 Tage zu stoppen Denn die Substanz JWH 018 faellt unter das Arzneimittelgesetz wurde aber bekanntlich vom Hersteller nicht angegeben Was ist denn nun dieser ominoese Stoff genau Die gefundene Substanz JWH 018 ist ein CB Rezeptor Agonist mit THC Wirkung und erklaert vollstaendig die durch Spice hervorgerufenen Effekte

images11 jpg
jwhformula.com
images11 jpg
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[source page]

JWH 018

From Yahoo Image Search: "JWH-018"
Thu Jul 29 13:10:33 2010

 JWH - 018 Addiction Potential as a Drug | Health Testing & Drug ...
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Wed, 19 May 2010 02:39:26 GM

Due to its pharmacological​ and metabolic characteristics​, . JWH. -. 018. is addictive and its prolonged use habit forming. As common for cannabinoids, intoxication and.

Understanding JWH - 018 | Health Testing & Drug Testing Guides ...
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Understanding JWH - 018 | Health Testing & Drug Testing Guides ...

TestCountry

Wed, 19 May 2010 02:27:28 GM

JWH. -. 018. is one of several hundred JWH compounds developed over the last few years by John W. Huffman (JWH), organic chemist, as part of research on analogues.

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hu, 13 May 2010 10:08:31 GM

Bk-MBDB,Bk-MDMA​,Buphedrone,Mep​hedrone,CP 47497,. JWH. -. 018. ,JWH-073,JWH-20​0,JWH-250,2C-C,​2C-D,2C-E,2C-I,​2C-P,2C-T-2,5-M​eO-DALT,Dimetho​caine,MDAI,MDPV​,O-Desmethyltra​madol . so please make your choice and get back to us as soon as possible . ...

From Google Blog Search: "JWH-018"
Thu Jul 29 18:26:47 2010