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Dexmethylphenidate (trade name Focalin, Novartis, generic by Teva also available), otherwise known as d-threo-methylphenidate (D-TMP), is the dextrorotatory enantiomer of methylphenidate. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant, which affects the CNS. Mode of activityMethylphenidate is a catecholamine reuptake inhibitor that indirectly increases catecholaminergic neurotransmission by inhibiting the dopamine transporter (DAT) and norepinephrine transporter (NET), which are responsible for clearing catecholamines from the synapse, particularly in the striatum and meso-limbic system. Although four stereoisomers of methylphenidate (MPH) are possible, only the threo diastereoisomers are used in modern practice. There is a high eudysmic ratio between the SS and RR enantiomers of MPH. "Dexmethylphenidate" is a preparation of the RR enantiomer of MPH. In theory, d-TMP can be anticipated to be twice the strength of the racemic product. However, certain authors recommend that the ratio is ~70% increase in potency upon enantiopurification of the racemate. Compd DAT (Ki) DA (IC50) NET (Ki) NE (IC50) D-TMP 161 23 206 39 L-TMP 2250 1600 >10K 980 DL-TMP 121 20 51 788From Wikipedia under the
GNU Free Documentation License What is the street name of Dexmethylphenidate Hydrochloride? Q. What is the street name of Dexmethylphenidate Hydrochloride? Asked by =MAF= - Wed Nov 29 19:24:59 2006 - - 2 Answers - 0 Comments A. Focalin is the brand name. It's not a street drug. But it's a mild stimulant. You can call it speed if you want to. Answered by cweetepye - Wed Nov 29 19:49:19 2006 any differences between METHYLPHENIDATE and DEXMETHYLPHENIDATE? Q. focalin was my new meds perscribed in stead of Ratlin. Am i going to feel anything different? Asked by jefferyjspencer - Mon Jan 22 22:30:53 2007 - - 1 Answers - 0 Comments A. One has dex in front of it lol just kidding i get goofy that late i wish i could help you but i cant have a good night :):):):):) Answered by wkdwchofwest - Mon Jan 22 22:38:28 2007 boyfriend did something stupid...he took some pills?
Q. my boyfriend took two 5mg tablets of 10mg Dexmethylphenidate (Focalin) which is a adhd medication. they are his nieces (she has adhd) meds and i just want to know what his reactions to it will be. i mean two 5mg tablets of Dexmethylphenidate not 2 10mg tablets so the fact that he is on a cleaning binge is normal then? Asked by April Thomason - Fri Feb 19 14:16:34 2010 - - 4 Answers - 0 Comments A. He'll be fine, you won't notice much of anything. He may seem more focused, maybe slightly over active. Nothing bad though. Answered by Alex0424 - Fri Feb 19 14:26:02 2010 From Yahoo Answer Search: "Dexmethylphenidate"
 news.google.com Reuters ... Dexmethylphenidate XR and Carvedilol CR, as well as a number of other important compounds in our product pipeline, including an early-stage innovation ... news.google.com Reuters IPC's lead product candidates include Dexmethylphenidate XR, a generic version of the marketed drug Focalin XR(R), which is partnered with Par ... From Google News Search: "Dexmethylphenidate" From Yahoo Image Search: "Dexmethylphenidate"  stop-whispering.livejournal.com Stop Whispering ue, 25 Sep 2007 05:00:21 GM i'm afraid. horrible nightmares. i don't know where to go. the doctor is all wrong. maybe i made a terrible mistake, and i am just making myself worse. i need another doctor. very self-destructive the past few days :( ...  familypart2005.spaces.live.com unknown hu, 30 Jun 2005 13:48:17 GM fda . dexmethylphenidate. hcl focalin xr merrem iv 50mg odt . yael waknine medscape medical news ...  biospacejobs.com unknown ue, 08 Jul 2008 12:00:01 GM East hanover, N.J., July 8 /PRNewswire/ -- A head-to-head study, published in the June Journal of Child and Adolescent Psychopharmacology, confirms that Focalin(R) XR (. dexmethylphenidate. HCl) extended-release capsules offer greater ... From Google Blog Search: "Dexmethylphenidate" |
MedlinePlus: Dexmethylphenidate
